Collectively, these findings suggest that our model of laser-induced brain injury in zebrafish reproduces mild TBI and can be a useful tool for TBI research and preclinical neuroprotective drug screening. The levels of hypoxia-inducible factor 1-alpha (Hif1a) increased 30 min after the injury, and recovered by Day 7, further supporting the construct validity of the model. A marker of microglial activation, Iba1, was elevated in the TBI brain, albeit decreasing from Day 3. The brain-derived neurotrophic factor (Bdnf) level in the brain dropped immediately after the trauma, but fully recovered seven days later. NeuN-positive cell staining was markedly reduced one day, but not seven days, after TBI, suggesting increased neuronal damage immediately after the injury, and its fast recovery. Overall, TBI induced hypolocomotion and anxiety-like behavior in the novel tank test, strikingly recapitulating responses in mammalian TBI models, hence supporting the face validity of our model. Here, we developed a novel model of non-invasive TBI induced by laser irradiation in the telencephalon of adult zebrafish (Danio rerio) and assessed their behavior and neuromorphology to validate the model and evaluate potential targets for neuroreparative treatment. Traumatic brain injury (TBI) is a major public health problem. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
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Medical tests of the forty-eight show their bone marrow will allow the Mountain Men to survive outside containment, so they begin taking the youths' bone marrow. These are transfusing blood from imprisoned grounders as an anti-radiation treatment as their bodies have not adapted to deal with the remaining radiation on Earth. In the second season, forty-eight of the remaining detainees are captured and taken to Mount Weather by the Mountain Men. Under the leadership of Clarke and Bellamy, the juveniles attempt to survive the harsh surface conditions, battle hostile grounders and establish communication with the Ark. They discover that some survived the apocalypse: the Grounders, who live in clans locked in a power struggle the Reapers, another group of grounders who have been turned into cannibals by the Mountain Men and the Mountain Men, who live in Mount Weather, descended from those who locked themselves away before the apocalypse. Three generations have been born in space, but when life-support systems on the Ark begin to fail, one hundred juvenile detainees are sent to Earth in a last attempt to determine whether it is habitable, or at least save resources for the remaining residents of the Ark. Ninety-seven years after a devastating nuclear apocalypse wipes out most human life on Earth, thousands of people now live in a space station orbiting Earth, which they call the Ark. Abby Griffin ( Paige Turco), Marcus Kane ( Henry Ian Cusick), and Chancellor Thelonious Jaha ( Isaiah Washington), all of whom are council members on the Ark, and Raven Reyes ( Lindsey Morgan), an engineer aboard the Ark. Other lead characters include Clarke's mother Dr. The main characters of juvenile prisoners includes Clarke Griffin ( Eliza Taylor), Finn Collins ( Thomas McDonell), Bellamy Blake ( Bob Morley), Octavia Blake ( Marie Avgeropoulos), Jasper Jordan ( Devon Bostick), Monty Green ( Christopher Larkin), and John Murphy ( Richard Harmon). The first people sent to Earth are a group of juvenile delinquents who encounter descendants of survivors of the nuclear disaster on the ground. The 100 follows post-apocalyptic survivors from a space habitat, the Ark, who return to Earth nearly a century after a devastating nuclear apocalypse. Developed by Jason Rothenberg, the series is loosely based on the young adult novel series of the same name by Kass Morgan. The 100 (pronounced The Hundred ) is an American post-apocalyptic science fiction drama television series that premiered on Maon The CW, and ended on September 30, 2020. This will be to up to £951 for 1 child or up to £1,630 for 2 or more children. If you think you need help with the costs at the time you pay them, you should discuss this with your work coach.īy this summer, working parents on Universal Credit will be able to receive even more financial help with their childcare costs. This means that you will usually pay the costs yourself, and Universal Credit will then pay you some of that money back.
Now, he is proving to be an enemy to our state by abandoning us in our greatest time of need," Texas Democratic Party Chair Gilberto Hinojosa said Thursday. "Ted Cruz had already proven to be an enemy to our democracy by inciting an insurrection. That stand led to calls for Cruz's resignation after a violent mob stormed the Capitol as Congress was affirming Biden's win. The Texas senator, who once described Trump as a "pathological liar," championed the-then president's call to block the certification last month of Democrat Joe Biden's election victory. In more recent years, he has positioned himself as a Trump loyalist with an eye toward a potential second White House bid. Capitol Police officials and the Senate Sergeant-at-Arms have encouraged lawmakers and their staff to be conscious of potential threats and to consider advising law enforcement about their travel at airports and other transportation hubs.Ĭruz has been criticized by detractors on both sides of the political spectrum even before he ran for president in 2016. The report, before Cruz's statement, only deepened when the Houston Police Department confirmed a member of the senator's staff contacted the department at Bush Intercontinental Airport on Wednesday to request assistance for Cruz's arrival. A source familiar with the senator's travel schedule told ABC News Cruz was scheduled to return to Texas on Saturday with his family. In saying yes to my daughters to somehow diminish all the Texans that were going through real hardship."Ĭruz's office told ABC News the senator tested for COVID-19 Thursday morning to comply with mandates on traveling to the U.S.Įarlier in the day, the Associated Press reported Cruz went for a long-planned trip to Cancun and was expected to return almost immediately, according to a source with direct knowledge of the situation who spoke on the condition of anonymity to share private conversations. It's unfortunate, the fire storm that came from it. I was trying to take care of my family," said Cruz. He told Eyewitness News he began feeling second thoughts the minute he sat down on the plane. let's go."Īfter his return to Houston, he quickly admitted that he regrets the decision to plan the getaway with his family. Let's go with some of our friends and let's get out of here and let's go somewhere warm," he recalled. The high-profile Republican lawmaker told Eyewitness News he and his family were among the many Texans who lost power. So, what was he thinking? Tom Abrahams asked Cruz that question to kick off the sit-down interview and the senator said he was simply trying to be a dad. HOUSTON, Texas (KTRK) - In a one-on-one interview with ABC13 from inside his home, Ted Cruz said he regrets taking a trip to Mexico as thousands of Texans remain without power and running water after a historic winter storm ravaged the state. "It was a mistake." The senator said admitted of his trip to Cancun amidst the Texas power crisis. Procedures have been presented in the literature in order toĭerive the reverberator structure considering the mixing timeĮvaluation and the minimization functions definition for the late Of research has been devoted in the last decades aiming toĪrtificially reproduce the reverberation effect exploiting a hybrid Reverberation is a well known effect that hasĪn important role in our listening experience. The study also discusses CPU usage for different FDN orders and plugin states. Experimenting with delay lengths and distribution demonstrates that choosing too wide or too narrow a length range is disadvantageous to the synthesized sound quality. The proposed plugin explores various FDN setups, showing that the lowest useful order for high-quality sound is 16, and that in the case of a Householder matrix the implementation strongly affects the resulting reverberation. It allows for control of reverberation time in ten octave bands, simultaneously allowing adjusting the feedback matrix type and delay-line lengths. The real-time implementation of an artificial reverberation synthesizer presented in this study introduces an audio plugin based on a feedback delay network (FDN), which lets the user have full and detailed insight into the produced reverb. Implementations that use an algorithmic approach are more flexible but do not let the users have full control over the produced sound, allowing only a few selected parameters to be altered. Although nowadays numerous real-time implementations of artificial reverberation algorithms are available, many of them depend on a database of recorded or pre-synthesized room impulse responses, which are convolved with the input signal. Reverberation is one of the most important effects used in audio production. Based on the results, the equivalent circuit adequately simulated the measured frequency response of the microspeaker and the estimations of the acoustic impedances of the ventilation cloths were in good agreement with the measured frequency responses of the microspeaker. Estimated value of the acoustic impedances of the ventilation cloths were used in an equivalent circuit model of the microspeaker for the simulated frequency responses and subsequently compared with the anechoic chamber measurements. The acoustic properties of the ventilation cloths were estimated from the measured frequency response of the microspeaker and by subsequent use of particle swarm optimization algorithm. The equivalent circuit model of the microspeaker was formulated by considering five types each of non-woven and woven ventilation cloths. Non-woven cloths (5 nos.) consist of irregular meshes and woven cloths (5 nos.) consist of regular meshes. Two types of ventilation cloths (acoustic cloths) are commonly used in electroacoustic products, non-woven and woven. The vents after the rear chamber of the microspeaker were covered with ventilation cloths. In this work, microspeaker frequency response was determined based on measurement and simulation. Further, subjective differences between FDN and Freeverb are not significant. Our method yields overall statistically significant higher scores with respect to other anchor conditions. We evaluated the method with a listening test to assess the similarity with target reverberation. The method has been implemented with two artificial reverberation algorithms: a Feedback Delay Network (FDN) and an implementation of the Schroeder-Moorer reverberator (Freeverb). Before this parameters optimization, the target early reflections are approximated through an autoregressive model. The matching between the approximation and the target is implemented with a perceptually motivated loss function. the approximated RIR, with the target one. This procedure iteratively tunes the artificial reverberator parameters to match its output, i.e. We used a Bayesian optimization procedure using a Gaussian Process as a prior distribution. The method automatically optimizes the parameters of an artificial reverberator to match a target Room Impulse Response (RIR). In this paper, we propose a method for reverb matching. An adequate matching provides a proper auditory immersion to the user. The matching of reverberation features between real sound sources and virtual ones is a key task in Audio Augmented Reality. Integrates with Google Calendar and Google Tasks, which makes being productive and organized easier.The Gmail Offline feature allows you to access emails and queue up emails to send when the app is back online.It is also integrated with other Google services, which work well on Android devices and is simple to add multiple Gmail accounts to one device.įor users with multiple email accounts, Gmail is compatible with services like and Yahoo Mail, or other IMAP or POP email accounts. Gmail works beautifully with Android, and it’s completely free. Gmail is the most frequently used email app with Android devices, and for good reason. Regular changes and updates to the Gmail user interface can leave users fatigued at constantly learning new features.īecause Gmail is a Google app, some users have privacy concerns associated with the depth of user information Google collects.Īdvertisements, though well-designed, are increasingly more present in Gmail. Emails and account information are not stored in the cloud, they are stored on your device, which means you never have to worry about a cloud-based security breach over which you have no control. Nine Email and Calendar does support multiple accounts and uses SSL security, but perhaps the most appealing feature of this email app for some users is that it is not cloud-based. It has the most common features found in email applications, including a rich text editor, global email address, and includes calendar and contacts functionality, but there is nothing groundbreaking in this app. If what you want is an email application that has a good user interface, but is simple and easy to use, then Nine Email and Calendar might be the right choice. There is a two-week free trial after which time functionality is limited unless the user pays extra. When you’re finished, mark the message as Done so you don’t have to wonder if you replied to a message or just thought about replying.Īutomatic syncing doesn’t always work well when roaming. Mark emails to be handled later and set reminders so nothing gets lost in your inbox again.Customizable swipe menu and email view actions for easy email management.Easily configurable rich text signatures that allow for stylized text and images.A Dark theme that automatically changes from day to night modes.Blue Mail also offers support for multiple email accounts. In our test, it took three taps to set up a Gmail account. Setting up an account in Blue Mail is super simple. It also offers support for IMAP, POP3, and Exchange, and it offers autoconfiguration. It works with multiple email providers, including Gmail, Yahoo Mail, AOL, Outlook, and Microsoft 365 among others. Unfortunately it is only available on Android, and therefore only classifies as an honorable mention in our list. The app can be buggy, especially right after an update which could require that you uninstall and reinstall to solve the problem and restore functionality.īlue Mail is a free, well-designed email app that offers tons of great features. Aqua Mail is a mail client with a good track record of user satisfaction (4/5 stars with 150k reviews on the Play Store), a rich set of features, and a decent free version. Eleven of his works have been turned into films, including Blade Runner, Total Recall, Minority Report, and A Scanner Darkly. Campbell Memorial Award in 1975, and was nominated five separate times for the Nebula Award. Electric Sheep is made by a collective intelligence consisting of hundreds of thousands of computers and people, all over the world, dreaming together. The author of 44 published novels and 120 short stories, Dick won a Hugo Award in 1963, and a John W. Dick would go on to become one of the most celebrated science fiction authors of all time. "A kind of pulp-fiction Kafka, a prophet." - The New York TimesĪbout the Author Born in Chicago in 1928, Philip K. "The most consistently brilliant science fiction writer in the world." -John Brunner that other authors shy away from." - Rolling Stone Dick "The most consistently brilliant science fiction writer in the world." -John Brunner "A kind of pulp-fiction Kafka, a prophet." - The New York Times " sees all the sparkling-and terrifying-possibilities. But when cornered, androids fight back-with lethal force. Rick Deckard, an officially sanctioned bounty hunter, is commissioned to find rogue androids and "retire" them. Driven into hiding, unauthorized androids live among human beings, undetected. Fearful of the havoc these artificial humans can wreak, the government bans them from Earth. Immigrants to Mars receive androids so sophisticated they are indistinguishable from true men or women. Those who remain covet any living creature, and for people who can't afford one, companies built incredibly realistic simulacra: horses, birds, cats, sheep. About the Book Originally published: New York: Doubleday and Co., 1968.īook Synopsis A masterpiece ahead of its time, a prescient rendering of a dark future, and the inspiration for the blockbuster film Blade Runnerīy 2021, the World War has killed millions, driving entire species into extinction and sending mankind off-planet. Īll software on the website is always listed as a percentage off at all times, the percentage varies twice a month, but the software has never been sold at the full price (Often over $100) References Software licenses only receive updates for 3 months, this is hardcoded into the application, no new features, bug fixes or security updates are received after this unless you go back to an unregistered version or buy a new license. Software nags to be run again after 14 days and application shortcuts on the desktop "wiggle" to prompt you to click on them. This behavior occurs despite the fact that only a sound processing program was installed on the user machine. For instance, right-click a tar file on your Windows machine and an option to download and install their file compression program appears. That said, if you install their software, they create context menus for several file types that are not at all related to an installed product. As of November 30, 2015, NCH Software is marked clean by all major antivirus products. In July 2015, NCH Software announced it was no longer bundling the Google toolbar. Controversy ĭuring 2013, some computer security companies categorized NCH software as bloatware because it bundled the Google Toolbar. This other software includes WavePad, a sound-editing program MixPad, a sound-mixing program PhotoPad, a photo and image editor Prism a video format converter Express Burn, disc burning software Switch, an audio format converter, Express Scribe, a transcription software and Debut, a screen recorder and video capture software. It is part of a suite that integrates with other software created by the company. VideoPad is the firm's video editing application for the home and professional market. On September 26, 2014, showed their most-frequently downloaded program from NCH Software was WavePad Sound Editor Masters Edition. NCH Software provides software programs for audio, video, business, dictation and transcription, graphics, telephony and other utilities. The Colorado office was started in April 2008 due to the large U.S. NCH Software is an Australian software company founded in 1993 in Canberra, Australia.
NOTE: All Ultra systems support up to three (3) 1RU Audio Breakout Modules which increases the total analog input matrix to twenty-four (24) and analog output matrix to fifteen (15). RAVE EXTERNAL 1RU AUDIO BREAKOUT MODULE (ABM)Īdjustable Pre-Amps Gain on Analog Inputs Per Channel Mute, Solo, & Pre-Fade Listen (PFL)Ĥ-band (high-shelf, dual midrange, low-shelf)ĭuplication of Mono channel (L or R) to create L-L / R-R channel pair *Requires external Audio Breakout Modules, support up to 3G SDIĪssignable to any SDI, AES or Analog source Sample Rate Converters (16-Channel SDI & Stereo AES inputs) HDBNC to BNC adapter cable kit (8 cables)Įnables comprehensive audio mixing and processing capabilities, including: ViewControl TM – Visual Production ControlĬarbonite Ultra Standard Power Supply (Brick)Įnable Frame Sync/Format Converters, Proc Amps & Color Correctors on all inputs & outputsĮnable 7 assignable Frame Sync/Format Converters, 4 assignable output Format Converters & 7 assignable Proc Amp/Color Correctors (Used with LiveEDL or MultiViewer Clock features) (Allows live transfer of XPression still graphics to Carbonite Ultra MediaStores) LIVE CG XPression graphic creation software included LiveEDL (generates a standard Edit Decision List for use in post-production) (Assignable to any Full ME or MiniME Keyer)Īllows for playout of ITU-T H.264 (MPEG-4 AVC) codec 1280×720 video clips (SD/HD video modes only)ĭirect Transfer of XPression Stills to MediaStores via Ethernet (Assignable to Full ME Transition Engines Internal Format Converters/Frame Synchronizers do not reduce the external SDI input matrix. NOTE: Internal sources, including MediaStores, ME, MiniME or Aux Bus re-entries, etc. (HD-BNC – Standard BNC Adaptors sold separately) 18 12G Single Link or 16 Single link +2 Single Link or Quad Link |